Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair

Precise genome editing in livestock is of great value for the fundamental investigation of disease modeling. However, genetically modified pigs carrying subtle point mutations were still seldom reported despite the rapid development of programmable endonucleases. Here, we attempt to investigate sing...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Wang, Kankan, Tang, Xiaochun, Liu, Yan, Xie, Zicong, Zou, Xiaodong, Li, Mengjing, Yuan, Hongming, Ouyang, Hongsheng, Jiao, Huping, Pang, Daxin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155319/
https://ncbi.nlm.nih.gov/pubmed/27898095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.101
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