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Otoferlin gene editing in sheep via CRISPR-assisted ssODN-mediated Homology Directed Repair
Different mutations of the OTOF gene, encoding for otoferlin protein expressed in the cochlear inner hair cells, induces a form of deafness that is the major cause of nonsyndromic recessive auditory neuropathy spectrum disorder in humans. We report the generation of the first large animal model of O...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7138848/ https://ncbi.nlm.nih.gov/pubmed/32265471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62879-y |
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