Otoferlin gene editing in sheep via CRISPR-assisted ssODN-mediated Homology Directed Repair

Different mutations of the OTOF gene, encoding for otoferlin protein expressed in the cochlear inner hair cells, induces a form of deafness that is the major cause of nonsyndromic recessive auditory neuropathy spectrum disorder in humans. We report the generation of the first large animal model of O...

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Publicado en:Sci Rep
Main Authors: Menchaca, A., dos Santos-Neto, P. C., Souza-Neves, M., Cuadro, F., Mulet, A. P., Tesson, L., Chenouard, V., Guiffès, A., Heslan, J. M., Gantier, M., Anegón, I., Crispo, M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138848/
https://ncbi.nlm.nih.gov/pubmed/32265471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62879-y
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