Otoferlin gene editing in sheep via CRISPR-assisted ssODN-mediated Homology Directed Repair

Different mutations of the OTOF gene, encoding for otoferlin protein expressed in the cochlear inner hair cells, induces a form of deafness that is the major cause of nonsyndromic recessive auditory neuropathy spectrum disorder in humans. We report the generation of the first large animal model of O...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Menchaca, A., dos Santos-Neto, P. C., Souza-Neves, M., Cuadro, F., Mulet, A. P., Tesson, L., Chenouard, V., Guiffès, A., Heslan, J. M., Gantier, M., Anegón, I., Crispo, M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138848/
https://ncbi.nlm.nih.gov/pubmed/32265471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62879-y
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