Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair

Precise genome editing in livestock is of great value for the fundamental investigation of disease modeling. However, genetically modified pigs carrying subtle point mutations were still seldom reported despite the rapid development of programmable endonucleases. Here, we attempt to investigate sing...

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Bibliografske podrobnosti
izdano v:Mol Ther Nucleic Acids
Main Authors: Wang, Kankan, Tang, Xiaochun, Liu, Yan, Xie, Zicong, Zou, Xiaodong, Li, Mengjing, Yuan, Hongming, Ouyang, Hongsheng, Jiao, Huping, Pang, Daxin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155319/
https://ncbi.nlm.nih.gov/pubmed/27898095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.101
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