Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair

Precise genome editing in livestock is of great value for the fundamental investigation of disease modeling. However, genetically modified pigs carrying subtle point mutations were still seldom reported despite the rapid development of programmable endonucleases. Here, we attempt to investigate sing...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Ther Nucleic Acids
Prif Awduron: Wang, Kankan, Tang, Xiaochun, Liu, Yan, Xie, Zicong, Zou, Xiaodong, Li, Mengjing, Yuan, Hongming, Ouyang, Hongsheng, Jiao, Huping, Pang, Daxin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155319/
https://ncbi.nlm.nih.gov/pubmed/27898095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.101
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