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Membrane-Bound Alpha Synuclein Clusters Induce Impaired Lipid Diffusion and Increased Lipid Packing

The aggregation of membrane-bound α-synuclein (αS) into oligomers and/or amyloid fibrils has been suggested to cause membrane damage in in vitro model phospholipid membrane systems and in vivo. In this study, we investigate how αS interactions that precede the formation of well-defined aggregates in...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Iyer, Aditya, Schilderink, Nathalie, Claessens, Mireille M.A. E., Subramaniam, Vinod
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153541/
https://ncbi.nlm.nih.gov/pubmed/27926845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.10.016
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