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C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets

[Image: see text] C-terminal truncations of monomeric wild-type alpha-synuclein (henceforth WT-αS) have been shown to enhance the formation of amyloid aggregates both in vivo and in vitro and have been associated with accelerated progression of Parkinson’s disease (PD). The correlation with PD may n...

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Publicat a:J Am Chem Soc
Autors principals: Iyer, Aditya, Roeters, Steven J., Kogan, Vladimir, Woutersen, Sander, Claessens, Mireille M. A. E, Subramaniam, Vinod
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668890/
https://ncbi.nlm.nih.gov/pubmed/28968082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07403
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