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C-Terminal Truncated α-Synuclein Fibrils Contain Strongly Twisted β-Sheets

[Image: see text] C-terminal truncations of monomeric wild-type alpha-synuclein (henceforth WT-αS) have been shown to enhance the formation of amyloid aggregates both in vivo and in vitro and have been associated with accelerated progression of Parkinson’s disease (PD). The correlation with PD may n...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Iyer, Aditya, Roeters, Steven J., Kogan, Vladimir, Woutersen, Sander, Claessens, Mireille M. A. E, Subramaniam, Vinod
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5668890/
https://ncbi.nlm.nih.gov/pubmed/28968082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07403
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