The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure

Human α-synuclein (αS) has been shown to be N terminally acetylated in its physiological state. This modification is proposed to modulate the function and aggregation of αS into amyloid fibrils. Using bacterially expressed acetylated-αS (NTAc-αS) and endogenous αS (Endo-αS) from human erythrocytes,...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Iyer, Aditya, Roeters, Steven J., Schilderink, Nathalie, Hommersom, Bob, Heeren, Ron M. A., Woutersen, Sander, Claessens, Mireille M. A. E., Subramaniam, Vinod
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076520/
https://ncbi.nlm.nih.gov/pubmed/27531743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.726612
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi