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Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells

BACKGROUND: Cortical motor neurons, also known as upper motor neurons, are large projection neurons whose axons convey signals to lower motor neurons to control the muscle movements. Degeneration of cortical motor neuron axons is implicated in several debilitating disorders, including hereditary spa...

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Detalhes bibliográficos
Publicado no:Front Biol (Beijing)
Main Authors: Denton, Kyle R., Xu, Chongchong, Shah, Harsh, Li, Xue-Jun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147749/
https://ncbi.nlm.nih.gov/pubmed/27956894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11515-016-1416-0
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