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Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells

BACKGROUND: Cortical motor neurons, also known as upper motor neurons, are large projection neurons whose axons convey signals to lower motor neurons to control the muscle movements. Degeneration of cortical motor neuron axons is implicated in several debilitating disorders, including hereditary spa...

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Bibliographic Details
Published in:Front Biol (Beijing)
Main Authors: Denton, Kyle R., Xu, Chongchong, Shah, Harsh, Li, Xue-Jun
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147749/
https://ncbi.nlm.nih.gov/pubmed/27956894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11515-016-1416-0
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