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Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias
Mechanisms by which long corticospinal axons degenerate in hereditary spastic paraplegia (HSP) are largely unknown. Here, we have generated induced pluripotent stem cells (iPSCs) from patients with two autosomal recessive forms of HSP, SPG15 and SPG48, which are caused by mutations in the ZFYVE26 an...
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| Pubblicato in: | Hum Mol Genet |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6031053/ https://ncbi.nlm.nih.gov/pubmed/29726929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy156 |
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