Lataa...
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Cdc25 phosphatases activate cyclin-dependent kinases (Cdks) and thereby promote cell cycle progression. In vertebrates, Chk1 and Chk2 phosphorylate Cdc25A at multiple N-terminal sites and target it for rapid degradation in response to genotoxic stress. Here we show that Chk1, but not Chk2, phosphory...
Tallennettuna:
| Julkaisussa: | EMBO J |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2004
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514503/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15272308/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600328 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|