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Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism

Cdc25 phosphatases activate cyclin-dependent kinases (Cdks) and thereby promote cell cycle progression. In vertebrates, Chk1 and Chk2 phosphorylate Cdc25A at multiple N-terminal sites and target it for rapid degradation in response to genotoxic stress. Here we show that Chk1, but not Chk2, phosphory...

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Main Authors: Uto, Katsuhiro, Inoue, Daigo, Shimuta, Ken, Nakajo, Nobushige, Sagata, Noriyuki
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2004
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC514503/
https://ncbi.nlm.nih.gov/pubmed/15272308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600328
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