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Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Cdc25 phosphatases activate cyclin-dependent kinases (Cdks) and thereby promote cell cycle progression. In vertebrates, Chk1 and Chk2 phosphorylate Cdc25A at multiple N-terminal sites and target it for rapid degradation in response to genotoxic stress. Here we show that Chk1, but not Chk2, phosphory...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group
2004
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514503/ https://ncbi.nlm.nih.gov/pubmed/15272308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600328 |
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