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Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
Cdc25 phosphatases activate cyclin-dependent kinases (Cdks) and thereby promote cell cycle progression. In vertebrates, Chk1 and Chk2 phosphorylate Cdc25A at multiple N-terminal sites and target it for rapid degradation in response to genotoxic stress. Here we show that Chk1, but not Chk2, phosphory...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514503/ https://ncbi.nlm.nih.gov/pubmed/15272308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600328 |
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