The Extracellular Signal-regulated Kinase–Mitogen-activated Protein Kinase Pathway Phosphorylates and Targets Cdc25A for SCF(β-TrCP)-dependent Degradation for Cell Cycle Arrest

The extracellular signal-regulated kinase (ERK) pathway is generally mitogenic, but, upon strong activation, it causes cell cycle arrest by a not-yet fully understood mechanism. In response to genotoxic stress, Chk1 hyperphosphorylates Cdc25A, a positive cell cycle regulator, and targets it for Skp1...

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Autores principales: Isoda, Michitaka, Kanemori, Yoshinori, Nakajo, Nobushige, Uchida, Sanae, Yamashita, Katsumi, Ueno, Hiroyuki, Sagata, Noriyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2009
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669026/
https://ncbi.nlm.nih.gov/pubmed/19244340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-01-0008
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