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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF(β-TrCP)
Wee1, the Cdc2 inhibitory kinase, needs to be down-regulated at the onset of mitosis to ensure rapid activation of Cdc2. Previously, we have shown that human somatic Wee1 (Wee1A) is down-regulated both by protein phosphorylation and degradation, but the underlying mechanisms had not been elucidated....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC384762/ https://ncbi.nlm.nih.gov/pubmed/15070733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307700101 |
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