M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF(β-TrCP)

Wee1, the Cdc2 inhibitory kinase, needs to be down-regulated at the onset of mitosis to ensure rapid activation of Cdc2. Previously, we have shown that human somatic Wee1 (Wee1A) is down-regulated both by protein phosphorylation and degradation, but the underlying mechanisms had not been elucidated....

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Bibliografische gegevens
Hoofdauteurs: Watanabe, Nobumoto, Arai, Harumi, Nishihara, Yoshifumi, Taniguchi, Makoto, Watanabe, Naoko, Hunter, Tony, Osada, Hiroyuki
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2004
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC384762/
https://ncbi.nlm.nih.gov/pubmed/15070733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307700101
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