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M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCF(β-TrCP)
Wee1, the Cdc2 inhibitory kinase, needs to be down-regulated at the onset of mitosis to ensure rapid activation of Cdc2. Previously, we have shown that human somatic Wee1 (Wee1A) is down-regulated both by protein phosphorylation and degradation, but the underlying mechanisms had not been elucidated....
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384762/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15070733/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307700101 |
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