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Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition
In Xenopus embryos, cell cycle elongation and degradation of Cdc25A (a Cdk2 Tyr15 phosphatase) occur naturally at the midblastula transition (MBT), at which time a physiological DNA replication checkpoint is thought to be activated by the exponentially increased nucleo-cytoplasmic ratio. Here we sho...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125399/ https://ncbi.nlm.nih.gov/pubmed/12110582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf357 |
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