Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

In Xenopus embryos, cell cycle elongation and degradation of Cdc25A (a Cdk2 Tyr15 phosphatase) occur naturally at the midblastula transition (MBT), at which time a physiological DNA replication checkpoint is thought to be activated by the exponentially increased nucleo-cytoplasmic ratio. Here we sho...

Descripción completa

Detalles Bibliográficos

Publicado en:	EMBO J
Autores principales:	Shimuta, Ken, Nakajo, Nobushige, Uto, Katsuhiro, Hayano, Yoshimasa, Okazaki, Kenji, Sagata, Noriyuki
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Publishing Group 2002
Materias:	Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12110582/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf357
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!