Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition

In Xenopus embryos, cell cycle elongation and degradation of Cdc25A (a Cdk2 Tyr15 phosphatase) occur naturally at the midblastula transition (MBT), at which time a physiological DNA replication checkpoint is thought to be activated by the exponentially increased nucleo-cytoplasmic ratio. Here we sho...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Shimuta, Ken, Nakajo, Nobushige, Uto, Katsuhiro, Hayano, Yoshimasa, Okazaki, Kenji, Sagata, Noriyuki
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2002
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125399/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12110582/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf357
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