SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer

PURPOSE: Methylation of the MGMT promoter is the major cause of O(6)-methylguanine methyltransferase deficiency in cancer and has been associated with the T variant of the promoter-enhancer SNP rs16906252C>T. We sought evidence for an association between the rs16906252C>T genotype and increase...

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Publicat a:Clin Cancer Res
Autors principals: Kuroiwa-Trzmielina, Joice, Wang, Fan, Rapkins, Robert W., Ward, Robyn L., Buchanan, Daniel D., Win, Aung Ko, Clendenning, Mark, Rosty, Christophe, Southey, Melissa C., Winship, Ingrid M., Hopper, John L., Jenkins, Mark A., Olivier, Jake, Hawkins, Nicholas J., Hitchins, Megan P.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143212/
https://ncbi.nlm.nih.gov/pubmed/27267851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2765
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