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SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer

PURPOSE: Methylation of the MGMT promoter is the major cause of O(6)-methylguanine methyltransferase deficiency in cancer and has been associated with the T variant of the promoter-enhancer SNP rs16906252C>T. We sought evidence for an association between the rs16906252C>T genotype and increase...

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Kuroiwa-Trzmielina, Joice, Wang, Fan, Rapkins, Robert W., Ward, Robyn L., Buchanan, Daniel D., Win, Aung Ko, Clendenning, Mark, Rosty, Christophe, Southey, Melissa C., Winship, Ingrid M., Hopper, John L., Jenkins, Mark A., Olivier, Jake, Hawkins, Nicholas J., Hitchins, Megan P.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143212/
https://ncbi.nlm.nih.gov/pubmed/27267851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2765
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