Risk of colorectal cancer for carriers of a germline mutation in POLE or POLD1

BACKGROUND: Germline mutations in the exonuclease domains of the POLE and POLD1 genes are associated with an as yet unquantified increased risk of colorectal cancer (CRC). METHODS: We identified families with POLE or POLD1 variants by searching PubMed for relevant studies prior to October 2016 and b...

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Bibliographic Details
Published in:Genet Med
Main Authors: Buchanan, Daniel D., Stewart, Jenna R., Clendenning, Mark, Rosty, Christophe, Mahmood, Khalid, Pope, Bernard J., Jenkins, Mark A., Hopper, John L., Southey, Melissa C., Macrae, Finlay A., Winship, Ingrid M., Win, Aung Ko
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943186/
https://ncbi.nlm.nih.gov/pubmed/29120461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2017.185
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