DNA Methylation Signatures and the Contribution of Age-Associated Methylomic Drift to Carcinogenesis in Early-Onset Colorectal Cancer

SIMPLE SUMMARY: The role of DNA methylation in the carcinogenesis of colorectal cancer (CRC) diagnosed <50 years of age (early-onset CRC or EOCRC) is currently unknown. In this study, we investigated the genome-wide DNA methylation of 97 tumour and 54 normal colonic mucosa samples from people wit...

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Veröffentlicht in:Cancers (Basel)
Hauptverfasser: Joo, Jihoon E., Clendenning, Mark, Wong, Ee Ming, Rosty, Christophe, Mahmood, Khalid, Georgeson, Peter, Winship, Ingrid M., Preston, Susan G., Win, Aung Ko, Dugué, Pierre-Antoine, Jayasekara, Harindra, English, Dallas, Macrae, Finlay A., Hopper, John L., Jenkins, Mark A., Milne, Roger L., Giles, Graham G., Southey, Melissa C., Buchanan, Daniel D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8199056/
https://ncbi.nlm.nih.gov/pubmed/34070516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13112589
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