Risk of colorectal cancer for carriers of a germline mutation in POLE or POLD1

BACKGROUND: Germline mutations in the exonuclease domains of the POLE and POLD1 genes are associated with an as yet unquantified increased risk of colorectal cancer (CRC). METHODS: We identified families with POLE or POLD1 variants by searching PubMed for relevant studies prior to October 2016 and b...

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Опубликовано в: :Genet Med
Главные авторы: Buchanan, Daniel D., Stewart, Jenna R., Clendenning, Mark, Rosty, Christophe, Mahmood, Khalid, Pope, Bernard J., Jenkins, Mark A., Hopper, John L., Southey, Melissa C., Macrae, Finlay A., Winship, Ingrid M., Win, Aung Ko
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943186/
https://ncbi.nlm.nih.gov/pubmed/29120461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2017.185
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