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Decreasing Distortion Energies without Strain: Diazo-Selective 1,3-Dipolar Cycloadditions

The diazo group has attributes that complement those of the azido group for applications in chemical biology. Here, we use computational analyses to provide insights into the chemoselectivity of the diazo group in 1,3-dipolar cycloadditions. Dipole distortion energies are responsible for ~80% of the...

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Bibliografiske detaljer
Udgivet i:J Org Chem
Main Authors: Gold, Brian, Aronoff, Matthew R., Raines, Ronald T.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141247/
https://ncbi.nlm.nih.gov/pubmed/27332711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.6b00948
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