Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

Myc family proteins promote cancer by inducing widespread changes in gene expression. Their rapid turnover by the ubiquitin–proteasome pathway is regulated through phosphorylation of Myc Box I and ubiquitination by the E3 ubiquitin ligase SCF(FbxW7). However, N-Myc protein (the product of the MYCN o...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Richards, Mark W., Burgess, Selena G., Poon, Evon, Carstensen, Anne, Eilers, Martin, Chesler, Louis, Bayliss, Richard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2016
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137718/
https://ncbi.nlm.nih.gov/pubmed/27837025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610626113
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller