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Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors
Myc family proteins promote cancer by inducing widespread changes in gene expression. Their rapid turnover by the ubiquitin–proteasome pathway is regulated through phosphorylation of Myc Box I and ubiquitination by the E3 ubiquitin ligase SCF(FbxW7). However, N-Myc protein (the product of the MYCN o...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137718/ https://ncbi.nlm.nih.gov/pubmed/27837025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610626113 |
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