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The structure of C290A:C393A Aurora A provides structural insights into kinase regulation
Aurora A is a Ser/Thr protein kinase that functions in cell-cycle regulation and is implicated in cancer development. During mitosis, Aurora A is activated by autophosphorylation on its activation loop at Thr288. The Aurora A catalytic domain (amino acids 122–403) expressed in Escherichia coli autop...
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| Udgivet i: | Acta Crystallogr F Struct Biol Commun |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
International Union of Crystallography
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356308/ https://ncbi.nlm.nih.gov/pubmed/25760707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15002290 |
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