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Detection of Ligand‐induced Conformational Changes in the Activation Loop of Aurora‐A Kinase by PELDOR Spectroscopy

The structure of protein kinases has been extensively studied by protein crystallography. Conformational movement of the kinase activation loop is thought to be crucial for regulation of activity; however, in many cases the position of the activation loop in solution is unknown. Protein kinases are...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:ChemistryOpen
Prif Awduron: Burgess, Selena G., Grazia Concilio, Maria, Bayliss, Richard, Fielding, Alistair J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167317/
https://ncbi.nlm.nih.gov/pubmed/28032021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/open.201600101
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