Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single‐Molecule Spectroscopy

The conformation of the activation loop (T‐loop) of protein kinases underlies enzymatic activity and influences the binding of small‐molecule inhibitors. By using single‐molecule fluorescence spectroscopy, we have determined that phosphorylated Aurora A kinase is in dynamic equilibrium between a DFG...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Gilburt, James A. H., Sarkar, Hajrah, Sheldrake, Peter, Blagg, Julian, Ying, Liming, Dodson, Charlotte A.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601181/
https://ncbi.nlm.nih.gov/pubmed/28700101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201704654
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