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Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation
Structure-based drug design is commonly used to guide the development of potent and specific enzyme inhibitors. Many enzymes – such as protein kinases – adopt multiple conformations, and conformational interconversion is expected to impact on the design of small molecule inhibitors. We measured the...
Enregistré dans:
| Publié dans: | Chem Sci |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Royal Society of Chemistry
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461105/ https://ncbi.nlm.nih.gov/pubmed/31015948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03669a |
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