Nalaganje...
Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation
Structure-based drug design is commonly used to guide the development of potent and specific enzyme inhibitors. Many enzymes – such as protein kinases – adopt multiple conformations, and conformational interconversion is expected to impact on the design of small molecule inhibitors. We measured the...
Shranjeno v:
| izdano v: | Chem Sci |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Royal Society of Chemistry
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6461105/ https://ncbi.nlm.nih.gov/pubmed/31015948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03669a |
| Oznake: |
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