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Ligand discrimination between active and inactive activation loop conformations of Aurora-A kinase is unmodified by phosphorylation

Structure-based drug design is commonly used to guide the development of potent and specific enzyme inhibitors. Many enzymes – such as protein kinases – adopt multiple conformations, and conformational interconversion is expected to impact on the design of small molecule inhibitors. We measured the...

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Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Gilburt, James A. H., Girvan, Paul, Blagg, Julian, Ying, Liming, Dodson, Charlotte A.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6461105/
https://ncbi.nlm.nih.gov/pubmed/31015948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc03669a
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