Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain

The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric inhibitors are generally more selective, but are difficult to identify bec...

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Bibliographic Details
Published in:Open Biol
Main Authors: Burgess, Selena G., Oleksy, Arkadiusz, Cavazza, Tommaso, Richards, Mark W., Vernos, Isabelle, Matthews, David, Bayliss, Richard
Format: Artigo
Language:Inglês
Published: The Royal Society 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4967828/
https://ncbi.nlm.nih.gov/pubmed/27411893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160089
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