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Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain
The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric inhibitors are generally more selective, but are difficult to identify bec...
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| Publicado no: | Open Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4967828/ https://ncbi.nlm.nih.gov/pubmed/27411893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160089 |
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