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Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly
The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A, promo...
में बचाया:
| में प्रकाशित: | PLoS Genet |
|---|---|
| मुख्य लेखकों: | , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Public Library of Science
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4489650/ https://ncbi.nlm.nih.gov/pubmed/26134678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005345 |
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