Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix

Aurora‐A regulates the recruitment of TACC3 to the mitotic spindle through a phospho‐dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these interactions, mediated by three motifs in a disordered region of TACC3. A hydrophobic docking motif binds to a p...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Burgess, Selena G, Mukherjee, Manjeet, Sabir, Sarah, Joseph, Nimesh, Gutiérrez‐Caballero, Cristina, Richards, Mark W, Huguenin‐Dezot, Nicolas, Chin, Jason W, Kennedy, Eileen J, Pfuhl, Mark, Royle, Stephen J, Gergely, Fanni, Bayliss, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897774/
https://ncbi.nlm.nih.gov/pubmed/29510984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797902
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados