Mitotic spindle association of TACC3 requires Aurora‐A‐dependent stabilization of a cryptic α‐helix

Aurora‐A regulates the recruitment of TACC3 to the mitotic spindle through a phospho‐dependent interaction with clathrin heavy chain (CHC). Here, we describe the structural basis of these interactions, mediated by three motifs in a disordered region of TACC3. A hydrophobic docking motif binds to a p...

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Publicat a:EMBO J
Autors principals: Burgess, Selena G, Mukherjee, Manjeet, Sabir, Sarah, Joseph, Nimesh, Gutiérrez‐Caballero, Cristina, Richards, Mark W, Huguenin‐Dezot, Nicolas, Chin, Jason W, Kennedy, Eileen J, Pfuhl, Mark, Royle, Stephen J, Gergely, Fanni, Bayliss, Richard
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5897774/
https://ncbi.nlm.nih.gov/pubmed/29510984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797902
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