Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A, promo...

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Publicat a:PLoS Genet
Autors principals: Burgess, Selena G., Peset, Isabel, Joseph, Nimesh, Cavazza, Tommaso, Vernos, Isabelle, Pfuhl, Mark, Gergely, Fanni, Bayliss, Richard
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489650/
https://ncbi.nlm.nih.gov/pubmed/26134678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005345
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