Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

The essential mammalian gene TACC3 is frequently mutated and amplified in cancers and its fusion products exhibit oncogenic activity in glioblastomas. TACC3 functions in mitotic spindle assembly and chromosome segregation. In particular, phosphorylation on S558 by the mitotic kinase, Aurora-A, promo...

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Publicado en:PLoS Genet
Autores principales: Burgess, Selena G., Peset, Isabel, Joseph, Nimesh, Cavazza, Tommaso, Vernos, Isabelle, Pfuhl, Mark, Gergely, Fanni, Bayliss, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489650/
https://ncbi.nlm.nih.gov/pubmed/26134678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005345
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