Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders

Anti-idiotypic binders which specifically recognize the variable region of monoclonal antibodies have proven to be robust tools for pharmacokinetic studies of antibody therapeutics and for the development of cancer vaccines. In the present investigation, we focused on the identification of anti-idio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Könning, Doreen, Rhiel, Laura, Empting, Martin, Grzeschik, Julius, Sellmann, Carolin, Schröter, Christian, Zielonka, Stefan, Dickgießer, Stephan, Pirzer, Thomas, Yanakieva, Desislava, Becker, Stefan, Kolmar, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575089/
https://ncbi.nlm.nih.gov/pubmed/28852148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10513-9
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