Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

Amplification of MYCN is a driver mutation in a subset of human neuroendocrine tumors including neuroblastoma. No small molecules that target N-Myc, the protein encoded by MYCN, are clinically available. N-Myc forms a complex with the Aurora-A kinase, which protects N-Myc from proteasomal degradatio...

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Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Brockmann, Markus, Poon, Evon, Berry, Teeara, Carstensen, Anne, Deubzer, Hedwig E., Rycak, Lukas, Jamin, Yann, Thway, Khin, Robinson, Simon P., Roels, Frederik, Witt, Olaf, Fischer, Matthias, Chesler, Louis, Eilers, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298657/
https://ncbi.nlm.nih.gov/pubmed/23792191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.05.005
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