Combined inhibition of Aurora-A and ATR kinase results in regression of MYCN-amplified neuroblastoma

Amplification of MYCN is the driving oncogene in a subset of high-risk neuroblastoma. The MYCN protein and the Aurora-A kinase form a complex during S phase that stabilizes MYCN. Here we show that MYCN activates Aurora-A on chromatin, which phosphorylates histone H3 at serine 10 in S phase, promotes...

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Detalhes bibliográficos
Publicado no:Nat Cancer
Main Authors: Roeschert, Isabelle, Poon, Evon, Henssen, Anton G., Garcia, Heathcliff Dorado, Gatti, Marco, Giansanti, Celeste, Jamin, Yann, Ade, Carsten P., Gallant, Peter, Schülein-Völk, Christina, Beli, Petra, Richards, Mark, Rosenfeldt, Mathias, Altmeyer, Matthias, Anderson, John, Eggert, Angelika, Dobbelstein, Matthias, Bayliss, Richard, Chesler, Louis, Büchel, Gabriele, Eilers, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610389/
https://ncbi.nlm.nih.gov/pubmed/33768209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43018-020-00171-8
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