GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly expressed in lung bronchial epithelium in human asthma. Overexpression of GSDMB in primary human bronchial epithelium increased expr...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Das, Sudipta, Miller, Marina, Beppu, Andrew K., Mueller, James, McGeough, Matthew D., Vuong, Christine, Karta, Maya R., Rosenthal, Peter, Chouiali, Fazila, Doherty, Taylor A., Kurten, Richard C., Hamid, Qutayba, Hoffman, Hal M., Broide, David H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135378/
https://ncbi.nlm.nih.gov/pubmed/27799535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610433113
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