GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly expressed in lung bronchial epithelium in human asthma. Overexpression of GSDMB in primary human bronchial epithelium increased expr...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Das, Sudipta, Miller, Marina, Beppu, Andrew K., Mueller, James, McGeough, Matthew D., Vuong, Christine, Karta, Maya R., Rosenthal, Peter, Chouiali, Fazila, Doherty, Taylor A., Kurten, Richard C., Hamid, Qutayba, Hoffman, Hal M., Broide, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135378/
https://ncbi.nlm.nih.gov/pubmed/27799535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610433113
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