GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation

Gasdermin B (GSDMB) on chromosome 17q21 demonstrates a strong genetic linkage to asthma, but its function in asthma is unknown. Here we identified that GSDMB is highly expressed in lung bronchial epithelium in human asthma. Overexpression of GSDMB in primary human bronchial epithelium increased expr...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Das, Sudipta, Miller, Marina, Beppu, Andrew K., Mueller, James, McGeough, Matthew D., Vuong, Christine, Karta, Maya R., Rosenthal, Peter, Chouiali, Fazila, Doherty, Taylor A., Kurten, Richard C., Hamid, Qutayba, Hoffman, Hal M., Broide, David H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135378/
https://ncbi.nlm.nih.gov/pubmed/27799535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1610433113
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars