Targeting epithelial ORMDL3 increases, rather than reduces, airway responsiveness and is associated with increased sphingosine-1-phosphate

類似資料

• ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma
  著者:: Miller, Marina, 等
  出版事項: (2014)
• Oroscomucoid like protein 3 (ORMDL3) transgenic mice have reduced levels of sphingolipids including sphingosine-1-phosphate and ceramide
  著者:: Miller, Marina, 等
  出版事項: (2016)
• ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6
  著者:: Miller, Marina, 等
  出版事項: (2012)
• GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation
  著者:: Das, Sudipta, 等
  出版事項: (2016)
• Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase
  著者:: Wang, Hsueh-Chun, 等
  出版事項: (2018)