Targeting epithelial ORMDL3 increases, rather than reduces, airway responsiveness and is associated with increased sphingosine-1-phosphate

In this study we used cre-lox techniques to generate mice selectively deficient in ORMDL3 in airway epithelium (Ormdl3(Δ2-3/Δ2-3)CC10) to simulate an inhaled therapy that effectively inhibited ORMDL3 expression in the airway. In contrast to the anticipated reduction in airway responsiveness (AHR), O...

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Bibliographic Details
Published in:J Immunol
Main Authors: Miller, Marina, Tam, Arvin B., Mueller, James L, Rosenthal, Peter, Beppu, Andrew, Gordillo, Ruth, McGeough, Matthew D., Vuong, Christine, Doherty, Taylor A., Hoffman, Hal M., Niwa, Maho, Broide, David H.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5399887/
https://ncbi.nlm.nih.gov/pubmed/28275141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601848
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