ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6

Orosomucoid like 3 (ORMDL3) has been strongly linked with asthma in genetic association studies, but its function in asthma is unknown. We demonstrate that in mice ORMDL3 is an allergen and cytokine (IL-4 or IL-13) inducible endoplasmic reticulum (ER) gene expressed predominantly in airway epithelia...

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Detalhes bibliográficos
Main Authors: Miller, Marina, Tam, Arvin B., Cho, Jae Youn, Doherty, Taylor A., Pham, Alexa, Khorram, Naseem, Rosenthal, Peter, Mueller, James L., Hoffman, Hal M., Suzukawa, Maho, Niwa, Maho, Broide, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478632/
https://ncbi.nlm.nih.gov/pubmed/23011799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204151109
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