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ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma
ORMDL3 (orosomucoid like 3) has been strongly linked with asthma in genetic association studies. As allergen challenge induces lung ORMDL3 expression in WT mice, we have generated human ORMDL3 Zona Pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that overexpress human ORMDL3 universally to investigate the r...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3981544/ https://ncbi.nlm.nih.gov/pubmed/24623133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303047 |
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