ORMDL3 transgenic mice have increased airway remodeling and airway responsiveness characteristic of asthma

ORMDL3 (orosomucoid like 3) has been strongly linked with asthma in genetic association studies. As allergen challenge induces lung ORMDL3 expression in WT mice, we have generated human ORMDL3 Zona Pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that overexpress human ORMDL3 universally to investigate the r...

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Detalhes bibliográficos
Main Authors: Miller, Marina, Rosenthal, Peter, Beppu, Andrew, Mueller, James L, Hoffman, Hal M., Tam, Arvin B., Doherty, Taylor A., McGeough, Matthew D., Pena, Carla A, Suzukawa, Maho, Niwa, Maho, Broide, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3981544/
https://ncbi.nlm.nih.gov/pubmed/24623133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1303047
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