Caricamento...
Structure-Guided Design of Novel Trypanosoma brucei Methionyl-tRNA Synthetase Inhibitors
A screening hit 1 against Trypanosoma brucei methionyl-tRNA synthetase was optimized using a structure-guided approach. The optimization led to the identification of two novel series of potent inhibitors, the cyclic linker and linear linker series. Compounds of both series were potent in a T. brucei...
Salvato in:
| Pubblicato in: | Eur J Med Chem |
|---|---|
| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5120670/ https://ncbi.nlm.nih.gov/pubmed/27788467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.10.024 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|