Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases

DNA-protein cross-links (DPCs) are bulky DNA lesions that form both endogenously and following exposure to bis-electrophiles such as common antitumor agents. The structural and biological consequences of DPCs have not been fully elucidated due to the complexity of these adducts. The most common site...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Wickramaratne, Susith, Ji, Shaofei, Mukherjee, Shivam, Su, Yan, Pence, Matthew G., Lior-Hoffmann, Lee, Fu, Iwen, Broyde, Suse, Guengerich, F. Peter, Distefano, Mark, Schärer, Orlando D., Sham, Yuk Yin, Tretyakova, Natalia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095413/
https://ncbi.nlm.nih.gov/pubmed/27621316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745257
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