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Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Roles of Translesion Synthesis DNA Polymerases

DNA-protein cross-links are formed upon exposure of cellular DNA to various agents, including antitumor drugs, UV light, transition metals, and reactive oxygen species. They are thought to contribute to cancer, aging, and neurodegenerative diseases. It has been proposed that DNA-protein cross-links...

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Vydáno v:Chem Res Toxicol
Hlavní autoři: Pande, Paritosh, Ji, Shaofei, Mukherjee, Shivam, Schärer, Orlando D., Tretyakova, Natalia Y., Basu, Ashis K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318270/
https://ncbi.nlm.nih.gov/pubmed/27951635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00397
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