5-Formylcytosine-induced DNA–peptide cross-links reduce transcription efficiency, but do not cause transcription errors in human cells

5-Formylcytosine (5fC) is an endogenous epigenetic DNA mark introduced via enzymatic oxidation of 5-methyl-dC in DNA. We and others recently reported that 5fC can form reversible DNA–protein conjugates with histone proteins, likely contributing to regulation of nucleosomal organization and gene expr...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Ji, Shaofei, Park, Daeyoon, Kropachev, Konstantin, Kolbanovskiy, Marina, Fu, Iwen, Broyde, Suse, Essawy, Maram, Geacintov, Nicholas E., Tretyakova, Natalia Y.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2019
Teme:
DNA and Chromosomes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6885644/
https://ncbi.nlm.nih.gov/pubmed/31597704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009834
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