Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells

DNA–protein cross-links can interfere with chromatin architecture, block DNA replication and transcription, and interfere with DNA repair. Here we synthesized a DNA 23-mer containing a site-specific DNA–peptide cross-link (DpC) by cross-linking an 11-mer peptide to the DNA epigenetic mark 5-formylcy...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Naldiga, Spandana, Ji, Shaofei, Thomforde, Jenna, Nicolae, Claudia M., Lee, Marietta, Zhang, Zhongtao, Moldovan, George-Lucian, Tretyakova, Natalia Y., Basu, Ashis K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615699/
https://ncbi.nlm.nih.gov/pubmed/31138652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008879
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