ERKing Trypanosoma: PCNA phosphorylation as novel target

Por Nicolae, Claudia M., Moldovan, George-Lucian
Publicado no Cell Cycle (2016)

Genome-wide CRISPR synthetic lethality screen identifies a role for the ADP-ribosyltransferase PARP14 in DNA replication dynamics controlled by ATR

Por Dhoonmoon, Ashna, Schleicher, Emily M, Clements, Kristen E, Nicolae, Claudia M, Moldovan, George-Lucian
Publicado no Nucleic Acids Res (2020)

PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress

Por Schleicher, Emily M, Galvan, Adri M, Imamura-Kawasawa, Yuka, Moldovan, George-Lucian, Nicolae, Claudia M
Publicado no Nucleic Acids Res (2018)

Loss of E2F7 confers resistance to poly-ADP-ribose polymerase (PARP) inhibitors in BRCA2-deficient cells

Por Clements, Kristen E, Thakar, Tanay, Nicolae, Claudia M, Liang, Xinwen, Wang, Hong-Gang, Moldovan, George-Lucian
Publicado no Nucleic Acids Res (2018)

Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

Por Thakar, Tanay, Leung, Wendy, Nicolae, Claudia M., Clements, Kristen E., Shen, Binghui, Bielinsky, Anja-Katrin, Moldovan, George-Lucian
Publicado no Nat Commun (2020)

The ADP-ribosyltransferase PARP10/ARTD10 Interacts with Proliferating Cell Nuclear Antigen (PCNA) and Is Required for DNA Damage Tolerance

Por Nicolae, Claudia M., Aho, Erin R., Vlahos, Alexander H. S., Choe, Katherine N., De, Subhajyoti, Karras, Georgios I., Moldovan, George-Lucian
Publicado em 2014

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

Por Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Clements, Kristen E., Stump, Coryn L., Nicolae, Claudia M., Moldovan, George-Lucian
Publicado no PLoS Genet (2020)

PARI overexpression promotes genomic instability and pancreatic tumorigenesis

Por O’Connor, Kevin W., Dejsuphong, Donniphat, Park, Eunmi, Nicolae, Claudia M., Kimmelman, Alec C., D’Andrea, Alan D., Moldovan, George-Lucian
Publicado em 2013

A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

Por Nicolae, Claudia M., Aho, Erin R., Choe, Katherine N., Constantin, Daniel, Hu, He-Juan, Lee, Deokjae, Myung, Kyungjae, Moldovan, George-Lucian
Publicado no Nucleic Acids Res (2015)

Error-prone replication of a 5-formylcytosine-mediated DNA-peptide cross-link in human cells

Por Naldiga, Spandana, Ji, Shaofei, Thomforde, Jenna, Nicolae, Claudia M., Lee, Marietta, Zhang, Zhongtao, Moldovan, George-Lucian, Tretyakova, Natalia Y., Basu, Ashis K.
Publicado no J Biol Chem (2019)

PARP10 deficiency manifests by infantile neurodegeneration and DNA repair defect

Por Shahrour, Maher Awni, Nicolae, Claudia M., Edvardson, Simon, Ashhab, Motee, Galvan, Adri M., Constantin, Daniel, Abu-Libdeh, Bassam, Moldovan, George-Lucian, Elpeleg, Orly
Publicado no Neurogenetics (2016)

HUWE1 interacts with PCNA to alleviate replication stress

Por Choe, Katherine N, Nicolae, Claudia M, Constantin, Daniel, Imamura Kawasawa, Yuka, Delgado‐Diaz, Maria Rocio, De, Subhajyoti, Freire, Raimundo, Smits, Veronique AJ, Moldovan, George‐Lucian
Publicado no EMBO Rep (2016)

Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive

Por Edvardson, Simon, Nicolae, Claudia M., Noh, Grace J., Burton, Jennifer E., Punzi, Giuseppe, Shaag, Avraham, Bischetsrieder, Jessica, De Grassi, Anna, Pierri, Ciro Leonardo, Elpeleg, Orly, Moldovan, George-Lucian
Publicado no Am J Hum Genet (2019)

FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

Por Awate, Sanket, Sommers, Joshua A, Datta, Arindam, Nayak, Sumeet, Bellani, Marina A, Yang, Olivia, Dunn, Christopher A, Nicolae, Claudia M, Moldovan, George-Lucian, Seidman, Michael M, Cantor, Sharon B, Brosh, Robert M
Publicado no Nucleic Acids Res (2020)

Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

Por Clements, Kristen E., Schleicher, Emily M., Thakar, Tanay, Hale, Anastasia, Dhoonmoon, Ashna, Tolman, Nathanial J., Sharma, Anchal, Liang, Xinwen, Imamura Kawasawa, Yuka, Nicolae, Claudia M., Wang, Hong-Gang, De, Subhajyoti, Moldovan, George-Lucian
Publicado no Nat Commun (2020)

STING promotes homeostasis via regulation of cell proliferation and chromosomal stability

Por Ranoa, Diana Rose E., Widau, Ryan C., Mallon, Stephen, Parekh, Akash D., Nicolae, Claudia M., Huang, Xiaona, Bolt, Michael J., Arina, Ainhoa, Parry, Renate, Kron, Stephen J., Moldovan, George-Lucian, Khodarev, Nikolai N., Weichselbaum, Ralph R.
Publicado no Cancer Res (2018)

Heterozygous De Novo UBTF Gain-of-Function Variant Is Associated with Neurodegeneration in Childhood

Por Edvardson, Simon, Nicolae, Claudia M., Agrawal, Pankaj B., Mignot, Cyril, Payne, Katelyn, Prasad, Asuri Narayan, Prasad, Chitra, Sadler, Laurie, Nava, Caroline, Mullen, Thomas E., Begtrup, Amber, Baskin, Berivan, Powis, Zöe, Shaag, Avraham, Keren, Boris, Moldovan, George-Lucian, Elpeleg, Orly
Publicado no Am J Hum Genet (2017)