Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors

The ataxia telangiectasia and Rad3-related (ATR) protein kinase is a key regulator of the cellular response to DNA damage. Due to increased amount of replication stress, cancer cells heavily rely on ATR to complete DNA replication and cell cycle progression. Thus, ATR inhibition is an emerging targe...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Schleicher, Emily M., Dhoonmoon, Ashna, Jackson, Lindsey M., Clements, Kristen E., Stump, Coryn L., Nicolae, Claudia M., Moldovan, George-Lucian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7660927/
https://ncbi.nlm.nih.gov/pubmed/33137164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009176
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